Transdermal Testosterone Therapy Improves Well-Being, Mood, and Sexual Function in Premenopausal Women

Transdermal Testosterone Therapy Improves Well-Being, Mood, and Sexual Function in Premenopausal Women

Transdermal Testosterone Therapy  | Compounding Pharmacy | Long BeachMany women in their 40’s report loss of libido, lowered mood, and fatigue. This can happen because testosterone levels decline with age in premenopausal women such that women in their 40’s have nearly half the circulating levels of women in their 20’s. The levels may further decline with preceding age.

Existing studies showing the benefits of testosterone on sexual function are limited to postmenopausal women, but no data is available with regard to its benefits in premenopausal women.

American Integrative Pharmacy is a leading compounding pharmacy and online prescription refills provider for patients in Long Beach, Torrance, Los Angeles, South Bay Orange County and other Southern California locations.

Study by the North American Menopause Society

The North American Menopause Society undertook a study to investigate the safety and efficacy of a physiological dose of testosterone, administered as a transdermal cream, on the overall well-being, sexual function, and mood in otherwise healthy premenopausal women who considered themselves to have low libido.

Women in the age group of 30 to 45, having a body mass index between 18 and 35 kg/m2, expressing diminished sexuality, and total testosterone of less than 2.2 nmol/L were chosen for the study. The protocol was a placebo controlled, crossover design with two double-blind, 12-week treatment periods separated by a single-blind, 4-week washout period. The participants were randomly assigned to the order in which they received testosterone or placebo treatment.

General Well-being Evaluation

Scientific scales were applied to assess the overall general well-being, including depressed mood, anxiety, self-confidence, positive well-being and general health, and vitality. Sexuality aspects were assessed for sexual interest, sexual activity, satisfaction of sexual life, experience of sexual pleasure, sexual fantasy, orgasm capacity, and sexual relevancy.

Safety Evaluation

Throughout the study, acne, voice changes, hirsutism, and any adverse events or changes in medication were recorded.


Effect on Serum Hormone Levels

The mean serum total testosterone increase by 0.22 nmol/L with placebo and 1.54 nmol/L with testosterone. The FAI increased by 0.4 with placebo and 3.6 with testosterone. The mean values for total testosterone remained within the normal female reproductive range, whereas the mean FAI rose to above the upper limit of normal with testosterone treatment.

Effect on General Well-being, Mood and Sexual Function

Significant improvements of 12.9 and 15.7 units were seen on the composite scores for Psychological General Well-Being Index and Sabbatsberg Sexual Self-Rating Scale respectively with testosterone in the per protocol analysis. The beneficial effect of testosterone was seen for all subscale scores of the Psychological General Well-Being Index.


Substantial and clinically meaningful improvements in psychological and sexual well-being were demonstrated in this study with transdermal testosterone therapy in healthy premenopausal women who had a primary complaint of low libido.

The improvement in the composite score of the Sabbatsberg Sexual Self-Rating Scale was large and persisted even after four weeks of treatment washout. Nearly half of the women had a 50 percent improvement in their individual sexual function score. In summary, the study demonstrated significant efficacy of transdermal testosterone therapy in women in their mid to late reproductive years on well-being and sexual function.


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American Integrative Pharmacy is located in Lomita, CA serving residents in and around Orange County, Los Angeles, Long Beach, Torrance and surrounding areas. Online prescription sales are available across the US.

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