Pyrimethamine/Curcumin is an anti-parasitic compound which is available in tablet form for oral intake. Every tablet of Pyrimethamine/Curcumin contains 50 mg pyrimethamine and 50 mg Curcumin. At times, it also contains active ingredients like lactose, corn and potato starch, and magnesium stearate.
American Integrative Pharmacy (AIP), led by the dedicated Dr. Neema Yazdanpanah, provides safe and proven compounding treatments to patients in Long Beach, Torrance, Los Angeles, South Bay Orange County, Southern California areas, and nationwide.
The body absorbs pyrimethamine well with peak levels happening between two and six hours after taking the medication. The body eliminates it gradually, and it has a plasma half-life of nearly 96 hours. Pyrimethamine is 87 percent bound human plasma proteins.
Pyrimethamine is a folic acid antagonist. The rationale behind its therapeutic activity finds its basis in the differential need between host and parasite for nucleic acid precursors involved in growth.
Indications and Usage
Treatment of Toxoplasmosis
Pyrimethamine is used to treat toxoplasmosis when combined with sulfonamide as there is synergy in this combination.
Treatment of Acute Malaria
Pyrimethamine is indicated to treat acute malaria as well. However, it should not be used in isolation in the treatment of acute malaria. Schizonticides that are fast-acting such as quinine or chloroquine are preferable and indicated to treat acute malaria. But the conjoint usage of Daraprim with a sulfonamide (for instance, sulfadoxine) will commence transmission control and subduing strains of plasmodia.
Chemoprophylaxis of Malaria
Pyrimethamine is indicated for the chemoprophylaxis of malaria because of vulnerable strains of plasmodia. But pyrimethamine resistance is a worldwide occurrence. It is not appropriate as a prophylactic agent for travelers to most regions.
Curcumin is the primary active ingredient in turmeric. It has robust anti-inflammatory properties and it is a powerful antioxidant. These are some of outstanding merits of curcumin:
- Reduces inflammation
- Encourages skin health
- Modulates blood sugar
- May have anti-cancer attributes
- May improve mental Health
- Prevents blood clots
- Alleviates joint pain
- Balances cholesterol
- Improves detoxification
- Boosts brain function
A significant advantage of curcumin is its ability to alleviate swelling in the body by hindering the activity of many enzymes involved in the process of inflammation. A human study on the comparison of the anti-inflammatory impacts of many compounds was published in Oncogene.
It identified that aspirin and ibuprofen which are two standard medications used in inflammation treatment, were the least powerful while curcumin extract was one of the most potent at relieving swelling.
Pyrimethamine dosage to treat toxoplasmosis is ten to twenty times the recommended dosage for antimalaria. It approaches the level of toxicity. If there are any symptoms of folate deficiency, decrease the dosage or do not use the medication as per the patient’s response.
Patients should be warned that at the first appearance of a skin rash they should stop the use of pyrimethamine and seek medical attention immediately.
Patients must understand that the appearance pallor, purpura, sore throat, or glossitis will warrant the pyrimethamine treatment to be halted. The patient should also seek medical treatment for these conditions.
American Integrative Pharmacy receives patients from Long Beach, Torrance, Los Angeles, South Bay Orange County, Southern California areas, and in every state in America for a wide range of compounding treatments.
American Integrative Pharmacy is located in Lomita, CA serving residents in and around Orange County, Los Angeles, Long Beach, Torrance and surrounding areas. Online prescription sales are available across the US.