Low Dose Naltrexone (LDN)
Low Dose Naltrexone (LDN) is the daily dosages of naltrexone that are around 10 percent or less of the usual opioid addiction treatment dosage, generally up to 5 mg.
These dosages necessitate a prescription and are compounded at compounding pharmacies.
American Integrative Pharmacy (AIP), led by Dr. Neema Yazdanpanah, provides compounding pharmacy treatments to patients in Long Beach, Torrance, Los Angeles, South Bay Orange County, Southern California areas, and nationwide.
Benefits of Low Dose Naltrexone (LDN)
Naltrexone presents paradoxical properties at the low dosage level, including anti-inflammatory actions and analgesia. These properties have not been reported at more substantial doses. Studies have proven that low dose Naltrexone (LDN) can be beneficial for individuals with conditions characterized by immune system dysfunction.
LDN is representative of the use of an established prescription drug in various other areas of medical treatment. While various studies have shown that LDV therapy is promising, more studies are being carried out to assess LDN effectiveness in addressing a range of autoimmune conditions.
LDN is often used along with traditional prescriptions drugs for the treatment of various illnesses, with the exception of narcotics.
Among others, LDN is prescribed for the following conditions:
- ALS (Lou Gehrig’s disease)
- Alzheimer’s disease
- Chronic fatigue syndrome
- Thyroid Disorders (Hashimoto’s and Graves’ Disease)
- Inflammatory bowel disease
- Multiple sclerosis (MS)
- Rheumatoid arthritis
- Ulcerative colitis
- LDN should be compounded at an accredited and well-established compounding pharmacy
- LDN should be initially given at 1.5 mg and increased over time
- LDN can be taken in the morning with fewer side-effects, such as insomnia or vivid dreams
- Response from LDN is expected at six weeks with maximum effects at 12 weeks
- Side-effects are uncommon but may include headache, GI disturbance, agitation, or flu-like symptoms
Types of LDN
- Liquid: Oral liquid formulation at 1 mg/ml
- Capsules: Available in various potencies ranging from 1.5 mg to 4.5 mg
- Sublingual drops: Developed for patients who find taking medicines to be challenging
- Cream: 0.5 mg/ml available for application on the skin, suitable for children
Patients who are taking a number of medicines and/or herbal supplements should consult a qualified physician or pharmacist prior to starting LDN. They should also consult their doctor if they have an impending medical procedure.
LDN is considered to be safe and well-tolerated. This is one of the most exciting facets of this medication. The side-effects are minimal and include sleep interruptions and vivid dreams during the early adjustment period. However, patients usually adjust quickly to the drug and these side-effects decrease over time.
LDN is compatible with a majority of prescription drugs with the exception of narcotics. LDN obstructs the effects of narcotics and may lead to withdrawal symptoms. Therefore, it should be started only those drugs are out of the system.
This drug is prescribed to Hashimoto’s patients with caution as it can lead to a prompt reduction in the autoimmune antibodies and may warrant a reduction in thyroid replacement medicines as the body functions more efficiently.
Key Clinical Studies
LDN has been the topic of much debate, but the drug has undergone very few clinical trials. For over two decades, Ian Zagon from Penn State University has been analyzing LDN and has conducted various preclinical studies evaluating LDN in cancer and in the animal model of MS.
These studies showed that LDN treatment brought about a significant improvement in symptoms as well as in bowel mucosal appearance.
Initially in a small pilot study, and more recently in a yet to be published controlled trial, Jared Younger from Stanford University has studied LDN in the treatment of Fibromyalgia. The results of the pilot study indicate a significant improvement in pain symptoms of these patients.
AIP provides both traditional and modern compounding pharmacy solutions, including online prescription refills to patients in Long Beach, Torrance, Los Angeles, South Bay Orange County, Southern California areas, and nationwide.
American Integrative Pharmacy is located in Torrance, CA serving residents in and around Orange County, Los Angeles, Long Beach and surrounding areas. Online prescription sales are available across the US.